Get difference between two lists with Unique Entries

I have two lists in Python:

temp1 = ['One', 'Two', 'Three', 'Four']
temp2 = ['One', 'Two']

Assuming the elements in each list are unique, I want to create a third list with items from the first list which are not in the second list:

temp3 = ['Three', 'Four']

Are there any fast ways without cycles and checking?